HEROIN
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Heroin is the cause for more deaths by overdose than any other single drug. The majority of these deaths ultimately result from respiratory failure. A toxic dose of heroin increases the inhibitory effect of GABA, which causes breathing to slow and eventually stop.
ALCOHOL
Alcohol overdoses occur predominantly in two ways. First, by decreasing the excitatory effect of glutamate, alcohol causes unconsciousness. At high levels, it can also cause breathing to slow or cease. Second, the body tries to rid itself of unabsorbed alcohol by emptying the stomach. If a person vomits while they are unconscious, they may inhale the vomit and compromise their breathing or even drown.
COCAINE
Cocaine can kill in a variety of ways, most commonly heart attack, overheating (hyperthermia), and brain damage. After taking even a low dose of cocaine, you are 24 times more likely than normal to have a heart attack.
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